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首页> 外文OA文献 >Discriminative Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans
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Discriminative Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans

机译：甲基苯丙胺的歧视性刺激和受试者评定的效应 d-苯丙胺，哌醋甲酯和三唑仑 甲基苯丙胺训练的人

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Methamphetamine abuse is a significant public health concern. Although widely studied in laboratory animals, little is known about the abuse-related behavioral effects of methamphetamine relative to other abused stimulants in controlled laboratory settings in humans. The aim of this study was to examine the discriminative stimulus, subject-rated, performance, and cardiovascular effects of methamphetamine in humans. In the present study, subjects first learned to discriminate 10 mg of oral methamphetamine from placebo. After acquiring the discrimination (≥80% drug-appropriate responding on four consecutive sessions), a range of oral doses of methamphetamine (2.5-15 mg), d-amphetamine (2.5-15 mg), methylphenidate (5-30 mg), and triazolam (0.0625-0.375 mg) was tested. Methamphetamine functioned as a discriminative stimulus and produced prototypical stimulant-like subject-rated effects. d-Amphetamine and methylphenidate produced dose-related increases in methamphetamine-appropriate responding, whereas triazolam did not. d-Amphetamine and methylphenidate produced stimulant-like behavioral effects, whereas triazolam produced sedative-like effects. Methamphetamine, but no other drug, increased heart rate, systolic pressure, and diastolic pressure significantly above placebo levels. Performance in the Digit-Symbol Substitution Test was not affected by any of the drugs tested. Overall, these results demonstrate that the acute behavioral effects of methamphetamine, d-amphetamine, and methylphenidate overlap extensively in humans, which is concordant with findings from preclinical studies. Future studies should assess whether the similarity in the behavioral effects of methamphetamine and related stimulants can be extended to other behavioral assays, such as measures of reinforcement, in humans.
机译：甲基苯丙胺滥用是一个重大的公共卫生问题。尽管在实验动物中进行了广泛研究，但在人体的受控实验室环境中，与甲基苯丙胺相对于其他滥用兴奋剂的滥用相关行为影响知之甚少。这项研究的目的是研究甲基苯丙胺对人的区别性刺激，受试者评价，表现和心血管效应。在本研究中，受试者首先学会了从安慰剂中区分出10 mg的口服甲基苯丙胺。在获得辨别力（连续四个疗程中≥80％的药物反应）后，口服一系列甲基苯丙胺（2.5-15毫克），d-苯异丙胺（2.5-15毫克），哌醋甲酯（5-30毫克），测试了三唑仑（0.0625-0.375 mg）。甲基苯丙胺起到区分性刺激的作用，并产生类似刺激物的受试者评价样机。 d-苯丙胺和哌醋甲酯可产生与剂量有关的甲基苯丙胺相应反应，而三唑仑则没有。 d-苯丙胺和哌醋甲酯产生类似兴奋剂的行为效果，而三唑仑产生类似镇静剂的效果。甲基苯丙胺（但没有其他药物）可使心率，收缩压和舒张压明显高于安慰剂水平。 Digit-Symbol替代测试的性能不受任何测试药物的影响。总体而言，这些结果表明，甲基苯丙胺，d-苯异丙胺和哌醋甲酯的急性行为影响在人体中广泛重叠，这与临床前研究的结果一致。未来的研究应评估甲基苯丙胺和相关兴奋剂在行为效果上的相似性是否可以扩展到其他行为分析中，例如对人体的增强作用。

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